AI-Powered Clinical Variant Interpretation & Decision Support
The industry’s biggest bottleneck is not sequencing — it’s interpretation. Clinicians and geneticists spend days manually reviewing variants against literature, databases, and clinical guidelines. Genomatis Interpret combines large language models, retrieval-augmented generation (RAG), and continuously updated genomic knowledge bases to automate ACMG/AMP variant classification, generate clinical reports in natural language, and provide treatment-aware decision support — all with full auditability and explainability.
LLM-Augmented Interpretation
Proprietary genomic language models fine-tuned on clinical literature, ClinVar, HGMD, COSMIC, and OMIM. Automated ACMG/AMP classification with evidence-traced reasoning for every call.
Automated Clinical Reports
Generates clinician-ready reports in natural language, including variant significance, therapeutic implications, pharmacogenomic interactions, and recommended follow-up — in the clinician’s preferred language.
RAG-Powered Knowledge Base
Retrieval-augmented generation system indexing 35M+ PubMed articles, clinical guidelines, and genomic databases. Every interpretation is backed by cited, verifiable sources.
Pharmacogenomic Integration
Built-in PGx analysis mapping patient genotypes to drug-gene interactions across 400+ medications. Flags dosage adjustments and contraindications directly within clinical reports.
Clinician-in-the-Loop Design
AI does not replace clinicians — it accelerates them. Every automated classification can be reviewed, overridden, and annotated. Full audit trail maintained for regulatory compliance.
| Capability | Traditional Tools | Genomatis Interpret |
|---|---|---|
| Variant classification | Manual / semi-auto | LLM-automated with evidence |
| Report generation | Hours per case | Minutes, auto-generated |
| Literature coverage | Point-in-time snapshots | Continuously updated RAG |
| PGx integration | Separate tool | Native, inline |
| Explainability | Black-box scores | Cited reasoning chains |
| Multilingual reports | English only | 12+ languages |